Amelioration of Pulmonary Emphysema by In Vivo Gene Transfection With Hepatocyte
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چکیده
Norihisa Shigemura, Yoshiki Sawa, Shinya Mizuno, Masamichi Ono, Mitsunori Ohta, Growth Factor in Rats Amelioration of Pulmonary Emphysema by In Vivo Gene Transfection With Hepatocyte Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000158433.89103.85 2005;111:1407-1414 Circulation. http://circ.ahajournals.org/content/111/11/1407 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Amelioration of pulmonary emphysema by in vivo gene transfection with hepatocyte growth factor in rats.
BACKGROUND Hepatocyte growth factor (HGF) is an important mitogen and morphogen that contributes to the repair process after lung injury. The goal of the present study was to characterize its role in pulmonary emphysema, which may lead to the development of new treatment strategies with HGF. METHODS AND RESULTS HGF mRNA and protein levels in lung tissue and plasma from elastase-induced emphys...
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Rationale and Objectives Although lung volume reduction surgery (LVRS) has been widely employed as a therapeutic strategy for pulmonary emphysema, the procedure carries significant disadvantages, including significant operative mortality and a limited duration of effective response. Pulmonary resection is known to elicit compensatory growth in remnant lung tissues, however, it remains unclear w...
متن کاملInduction of compensatory lung growth in pulmonary emphysema improves surgical outcomes in rats.
RATIONALE AND OBJECTIVES Although lung volume reduction surgery (LVRS) has been widely used as a therapeutic strategy for pulmonary emphysema, the procedure carries significant disadvantages, including significant operative mortality and a limited duration of effective response. Pulmonary resection is known to elicit compensatory growth in remnant lung tissues; however, it remains unclear wheth...
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Pulmonary emphysema is a progressive disease with airspace destruction and an effective therapy is needed. Keratinocyte growth factor (KGF) promotes pulmonary epithelial proliferation and has the potential to induce lung regeneration. The aim of this study was to determine the possibility of using KGF gene therapy for treatment of a mouse emphysema model induced by porcine pancreatic elastase (...
متن کاملAmelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages.
Directed gene transfer into specific cell lineages in vivo is an attractive approach for both modulating gene expression and correcting inherited mutations such as emphysema caused by human alpha1 antitrypsin (hAAT) deficiency. However, somatic tissues are mainly comprised of heterogeneous, differentiated cell lineages that can be short lived and difficult to specifically transfect. Here, we de...
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تاریخ انتشار 2005